Mechanics of Soft/Bio Materials

WELCOME TO THE RAZAVI RESEARCH GROUP

Mechanics of Soft/Bio Materials Lab

Welcome to the research group website of Mir Jalil Razavi, an assistant professor of mechanical engineering for the Thomas J. Watson College of Engineering and Applied Science at 91社区 (State University of New York).

In our group, we try to understand the mechanical properties and behavior of materials in both engineering and biology using theoretical analysis, computational modeling and experimental investigation.

Our current research focuses on the study of physics and characterization of soft materials, especially growth and remodeling of soft biological tissues (such as the brain and skin) to understand the fundamental principles of growth, morphological instability and post-instability pattern selection of living tissues.

Research

The following research topics are some of our ongoing projects.

brain

(a) 3-hinges in a brain has higher concentration of axon fibers. (b) Red dots show identified 3-hinges in a small part of the real brain image. (c) Non-linear finite element model mimics formation of 3-hinges in a growing brain.

Mechanics of the growth and folding of brain

The mechanical behavior of soft materials is strongly nonlinear from both physical (constitutive equations) and geometrical (large deformations) standpoints, which makes its study challenging.

The brain is a good example of soft matter with complex structure and function. We are doing research in the theoretical and computational modeling of growth, instability and folding of a growing brain. Brain mechanics is a fully interdisciplinary research area that integrates multiple scientific, engineering and computational disciplines.

The goal of this research is developing innovative computational and technological approaches to study the links between brain growth and post-instability morphogenesis. This effort will lead to new insights into topics such as fundamental mechanisms for development and organization of cerebral cortex. 

skin

Mechanics of wrinkling and aging of skin

A major concern associated with skin, the largest organ of our bodies, is how to prevent it from wrinkling and aging. Understanding the mechanics of skin wrinkling can provide useful insight into skin aging prevention. However, despite decades of research, the underlying mechanism of skin wrinkling and aging remains poorly understood. We explore the effect of geometrical and mechanical properties of skin on its wrinkling through an integrated theoretical and computational analysis.

instability

(a) Growth of a soft tube in a confined boundary. (b) Surface nano-creasing of a polymeric brush. (c) Creating 3D structures by thermoresponsive fibers.

Mechanics of instability and
morphogenesis of soft materials/tissues

Growth, morphological instabilities and post-instability surface patterns of soft materials such as elastomers, polymeric gels and biological soft tissues are a hot topic to a number of research fields, including functional material, soft lithography, flexible electronics and biomedical engineering.

Morphological surface instability of soft materials with a wide-ranging application has attracted great interest among academics over the past decade. Growth and creasing of solid tumors, wrinkling of mucosa in the esophagus, rippling of leaves, buckling of artery, surface wrinkling and creasing of a swelling hydrogel, and wrinkling of the gut all are examples of growth and remodeling of soft tissues which undergo large deformation and acquire various morphological instabilities in response to self or environmental stimuli. Therefore, we try by analytical, computational and experimental effort to explore characteristics of surface patterns as well as understanding the underlying physical mechanisms in different types of materials and tissues.

electrospun

A mechanical model for the electrospun fibrous mat under biaxial tension with bonding between intersecting fibers.

Mechanics of electrospun fibrous mats

Electrospun fibrous mats, characterized by their large surface-to-volume ratios, have unique and beneficial properties for various applications. The micro- or nanoscale architectures of these structures affects the mechanical properties of the material.

The lack of knowledge for predicting the mechanical behavior of electrospun fibrous mats may prevent applications utilizing these mats from reaching their full potential. In this project, we try by multiscale modeling techniques to link the behavior of the bulk material to the microstructure architecture.

Group members

Principal investigator razavi

Mir Jalil Razavi received his MS degree in solid mechanics from University of Tabriz in 2009 and his PhD degree in engineering (mechanics and materials) from the University of Georgia in 2018. He joined the mechanical engineering department at 91社区 in fall 2018.

Razavi has published several peer-reviewed journal and conferences papers in the mechanics of soft materials. 

Graduate Students chavoshnejad

Poorya Chavoshnejad
PhD student

Ali Hoseinzadeh Foroughi Foroughi
PhD Student

Akbar Solhtalab akbar-solhtalab
PhD Student

  • MS: Amirkabir University of Technology
  • BS: University of Tabriz
  • Email: asolhta1@binghamton.edu

Publications

  •  P. Chavoshnejad, L. Vallejo, S. Zhang, Y. Guo, W. Dai, T. Zhang, M.J. Razavi. "Mechanical hierarchy in the formation and modulation of cortical folding patterns." Scientific Reports 13, no. 1 (2023): 13177.  

  • P. Chavoshnejad, L. Chen, X. Yu, J. Hou, N. Filla, D. Zhu, T. Liu, G. Li, M.J. Razavi, X. Wang. "An integrated finite element method and machine learning algorithm for brain morphology prediction." Cerebral Cortex (2023): bhad208.  

  • A. H. Foroughi, C. Valeri, D. Jiang, F. Ning, M. Razavi, M.J. Razavi. "Understanding compressive viscoelastic properties of additively manufactured PLA for bone-mimetic scaffold design." Medical Engineering & Physics 114 (2023): 103972.  

  • A. H. Foroughi, M. J. Razavi, "Multiobjective Shape Optimization of Bone Scaffolds: Enhancement of Mechanical Properties and Permeability", 2022, Acta Biomaterialia.  
  • A. H. Foroughi, M. J. Razavi, "Shape optimization of orthopedic porous scaffolds to enhance mechanical performance.", 2022, Journal of the Mechanical Behavior of Biomedical Materials,  
  • M. K. Razavi Aghjeh, M. J. Razavi, "Effect of interfibre bonding on mechanical behaviour of electrospun fibrous mats'', 2022, In Mechanics of Fibrous Networks (pp. 317-354). Elsevier.  
  • P. Chavoshnejad, G. German, M.J. Razavi, "Hyperelastic Material Properties of Axonal fibers in Brain White Matter", 2021, Brain Multiphysics, .
  • P. Chavoshnejad, A. H.Foroughi, N. Dhandapani, G. German, M.J. Razavi, " Effect of collagen degradation on the mechanical behavior and wrinkling of skin", 2021, Physical Review Letters E, .
  • N. Liu, P. Chavoshnejad, S. Li, M.J. Razavi, T. Liu, R. Pidaparti, X. Wang, "Geometrical nonlinear elasticity of axon under tension: A coarse-grained computational study", 2021, Biophysical Journal,  

  • M.J.Razavi, T.Liu, X. Wang, "Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition'', 2021, Cerebral Cortex Communications,

  • P. Chavoshnejad, X. Li, S. Zhang, W. Dai, L. Vasung, T. Liu, T. Zhang, X. Wang, M.J.Razavi," Role of Axonal Fibers in the Cortical Folding Patterns: A Tale of Variability and Regularity", 2021, Brain Multiphysics,

  • P. Chavoshnejad, O. Alsmairat, C. Ke, M.J.Razavi, "Effect of interfiber bonding on the rupture of electrospun fibrous mats'', 2020, Journal of Physics D: Applied Physics,  
  • M. Brown, M. Mendoza, P. Chavoshnejad, M. J. Razavi, G. Mahler, A. Koh, 鈥淓lectronic鈥怑CM: A Permeable Microporous Elastomer for an Advanced Bio鈥怚ntegrated Continuous Sensing Platform鈥, 2020, ADVANCED MATERIAL TECHNOLOGIES,
  • P. Chavoshnejad, M. J. Razavi, 鈥淓ffect of the Interfiber Bonding on the Mechanical Behavior of Electrospun Fibrous Mats鈥, 2020, Scientific Reports 10 (7709 (2020)),
  • P. Chavoshnejad, S. More, M. J. Razavi, 鈥淔rom surface microrelief to big wrinkles in skin: A mechanical in-silico model鈥, Extreme Mechanics Letter, .
  • N. A. Hossain, M. J. Razavi, S. Towfighian, 鈥淎nalysis of mechanical deformation effect on the voltage generation of a vertical contact mode triboelectric generator鈥, Journal of Micromechanics and Microengineering, .
  • T. Zhang, H. Chen, M.J. Razavi, Y. Li, F. Ge, L. Gue, X. Wang, T. Liu, 鈥淓xploring 3-hinge gyral folding patterns among HCP Q3 868 human subjects鈥, 2018, Human Brain Mapping.  
  • F. Ge, X. Li, M.J. Razavi, H. Chen, T. Zhang, S. Zhang, L. Guo, X. Hu, X. Wang, T. Liu, 鈥淒enser Growing Fiber Connections Induce 3-hinge Gyral Folding鈥, 2017,
  • M.J. Razavi, T. Zhang, H. Chen, S. Platt, Y. Zhao, L. Guo, X. Hu, X. Wang and T. Liu, 鈥淩adial Structure Scaffolds the Convolution Patterns of Developing Cerebral Cortex鈥, Frontiers in Computational Neuroscience, 2017,
  • M.J. Razavi, M. Reeves, X. Wang, 鈥淢echanical role of a growing solid tumor on cortical folding鈥, Computer Methods in Biomechanics and Biomedical Engineering, 2017, 20(11), 1212-1222.  
  • K. Brooks, M.J. Razavi, X. Wang, J. Locklin, 鈥淭he evolution of creased morphologies using reactive droplets in ultrathin films鈥, Advance Material Interface, 2017,
  • X. Li, H. Chen, T. Zhang, X. Yu, X. Jiang, K. Li, L. Li, M.J. Razavi, X. Wang, X. Hu, J. Han, L. Guo, X. Hu, T. Liu, 鈥淐ommonly preserved and species-specific gyral folding patterns across primate brains鈥, Brain Structure and Function, 2017, 222(5), 2127-2141. DOI: 10.1007/s00429-016-1329-3
  • G. Stoychev, M.J. Razavi, X. Wang, L. Ionov, 鈥4D origami by smart embroidery鈥, Macromolecular Rapid Communications, 2017,   
  • T. Zhang, M.J. Razavi, H. Chen, Y. Li, X. Li, L. Li, L. Guo, X. Hu, T. Liu, X. Wang, 鈥淢echanisms of circumferential gyral convolution in primate brains鈥. Journal of Computational Neuroscience, 2017, 42, 217-229.  
  • T. Zhang, M.J. Razavi, X. Li, H. Chen, T. Liu, X. Wang, 鈥淢echanism of Consistent Gyrus Formation: an Experimental and Computational Study鈥, Scientific Reports, 2016, 6 (37272).
  • M.J. Razvavi, R. Pidaparti, X. Wang, 鈥淪urface and interfacial creases in a bilayer tubular soft tissue鈥, Physical Review E, 2016, 94 (022405).
  • K. Brooks, M.J. Razavi, X. Wang, J. Locklin, 鈥淣anoscale Surface Creasing Induced by Post-Polymerization Modification鈥, ACS Nano, 2015, 5b04144.
  • M.J. Razavi, T. Zhang, T. Liu, X. Wang, 鈥淐ortical Folding Pattern and its Consistency Induced by Biological Growth鈥, Scientific Reports, 2015, 5, 14477.
  • M.J. Razavi, T. Zhang, X. Li, T. Liu, X. Wang, 鈥淩ole of mechanical factors in cortical folding development鈥, Physical Review E, 2015, 92 (3), 032701.  
  • M.J. Razavi, X. Wang, 鈥淢orphological patterns of a growing biological tube in a confined environment with contacting boundary鈥, RSC Advances, 2015, 5 (10), 7440-7449.
  • T.N. Chakherlou, M.J. Razavi, A.B. Aghdam, B. Abazadeh,鈥淎n experimental investigation of the bolt clamping force and friction effect on the fatigue behaviour of aluminum alloy 2024-T3 double shear lap joint鈥 , Materials & Design, 2011, 32 (8-9), 4641-4649.
  • T.N. Chakherlou, M.J. Razavi, A.B. Aghdam,鈥 On the variation of clamping force in bolted double lap joints subjected to longitudinal loading: A numerical and experimental investigation鈥, Strain: An International Journal for Experimental Mechanics, 2012, 48 (1), 21-29.  
  • T.N. Chakherlou, M.J. Razavi, B. Abazadeh,鈥淔inite Element investigations of bolt clamping force and friction coefficient effect on the fatigue behaviour of aluminum alloy 2024-T3 in double shear lap joint鈥, Engineering Failure Analysis, 2013, 29, 62-74.
  • M.R. Khoshravan, A. Khalili, M.J.Razavi, 鈥淣umerical Analysis of the Effect of Added hole on the Stress Concentration of a Perforated Plate and Determining of Its Optimum Location鈥, Key Engineering Materials, Vols. 452-453, Advances in Fracture and Damage Mechanics IX, 2011, 793-796.

Research positions

We invite applications for PhD graduate fellowship positions and visiting scholar positions. The preferred areas of interest are in solid mechanics. Qualified candidates are expected to have a master's degree (preferred) or bachelor's degree in mechanical engineering, engineering mechanics, physics or related disciplines. Experience with modeling and simulation based on finite element model is essential. Please send your CV to Professor Razavi.

Many research topics are available for current master's and bachelor's students at 91社区. The projects are related to analytical and computational study of mechanics of soft biological tissues and mechanical behavior of solid structures. Please send your CV and interested research area to Professor Razavi to have more discussion.